Chemokines: the (un)usual suspects in pancreatic cancer neural invasion

Demir, I. E., and Mota Reyes, C. (2020). Nat Rev Gastroenterol Hepatol 8(4):221-222. doi: 10.1038/s41575-020-0329-1


Pancreatic cancer is notorious for its affinity for invading nerves. A new study using a systematic unbiased RNA-interference screen of neuronal chemokines in cocultures of mouse sensory neurons and pancreatic cancer cells has now identified CCL21 and CXCL10 as key mediators of neural invasion, neural remodelling and pain in pancreatic cancer.