High levels of modified ceramides are a defining feature of murine and human cancer cachexia

The teams of Mauricio Berriel Diaz (Principal investigator of P09) and Maria Rohm performed lipidomics on plasma of cachexia models and cancer patients and identified specific lipid species as a hallmark of cancer-associated weight loss.

Cancer cachexia (CCx) is a multifactorial energy‐wasting syndrome reducing the efficiency of anti‐cancer therapies, quality of life, and survival of cancer patients. In the past years, most studies focused on the identification of tumour and host‐derived proteins contributing to CCx. However, there is still a lack of studies addressing the changes in bioactive lipids. The aim of this study was to identify specific lipid species as a hallmark of CCx by performing a broad range lipid analysis of plasma from well‐established CCx mouse models as well as cachectic and weight stable cancer patients.

For more information read our new publication in the Journal of Cachexia, Sarcopenia and Muscle:

Photo: Pauline Morigny, Maria Rohm, Julia Zuber, Mauricio Berriel Diaz