Functional characterization of neuropathy and neural invasion (NI) in genetically engineered mouse models (GEMM) of pancreatic ductal adenocarcinoma (PDAC)

Principal Investigator: Prof. Güralp O. Ceyhan (Klinik und Poliklinik für Chirurgie, Klinikum rechts der Isar, TUM)

The aim of our project is a comprehensive mechanistic understanding of the nerve-cancer interactions in PDAC. Neuroinvasion will be characterized in a panel of GEMM in vivo and in vitro to define genetic and signalling events mediating NI. PiggyBac transposon mutagenesis will be used as an unbiased approach to discover novel genes driving NI. Targets will be validated on human tissue cohorts and functionally tested using organoid-neuron co-cultures. The long-term goal is the development of therapeutic concepts interfering with NI.