Open positions
The Department of Internal Medicine II, the Institute of Translational Cancer Research and Experimental Cancer Therapy at TUM and the German Cancer Research Center offer PhD student (f/m/d) positions in Cancer Biology/Immunology and Bioinformatics at the Center for Translational Cancer Research (TranslaTUM) in Munich.
We are deploying genetic models and bioinformatics to study molecular, immunological and translational aspects of pancreatic cancer. One focus in the past few years was the development of novel preclinical models and organoid-based orthotopic transplantation strategies to mechanistically analyze subtypes of pancreatic cancer. The focus of the advertised projects will be on the identification and functional validation of novel therapeutic targets with a focus on tumor cell intrinsic as well as inflammatory pathways that are required for tumor initiation and progression in vivo (e.g. Nature Reviews Cancer 2020, Oct;20(10):573-593, Nature 2018, 554:62-68; Nat. Rev. Cancer 2017 17:239-253; Nat. Commun. 2016, 7:10770; Nat Med. 2014, 20:1340-7; Cancer Cell. 2013,24:15-29, Cancer Cell. 2013,23:406-20, Nat Commun. 2013;4:1630; PNAS 2011, 108:9945-50).
We are an enthusiastic team and offer intensive training and mentoring. The successful candidates will have the opportunity to learn a wide spectrum of genetic, molecular and cell biology, biochemical as well as immunological and bioinformatics techniques. They will be exposed to cutting edge methods to study translational aspects of cancer (e.g. Cre/loxP and Flp/FRT based dual- and triple recombinase systems, organoid culture, orthotopic transplantations of organoids, CRISPR/Cas9, molecular in vivo imaging, in vivo transposon mutagenesis, RNA and exome sequencing, single cell sequencing, spatial transcriptomics, histocytometry). They will also be able to gain insights into clinically relevant aspects of cancer development through proximity to the clinical facilities and through the interdisciplinary composition of our team and closely collaborating groups.
The successful candidates will be employed under the umbrella of the German Cancer Consortium (DKTK/DKFZ/TUM) as well as at the Institute for Experimental Cancer Therapy at Klinikum rechts der Isar university hospital of the Technical University of Munich (www.exp-cancertherapy.med.tum.de/en). The Institute is located at the newly built Center for Translational Cancer Research, TranslaTUM, in the heart of Munich.
Your profile:
- Diploma or Masters degree in bioinformatics, biochemistry, biology, molecular/translational medicine or related subjects
- Previous exposure to and experience with basic biochemical and molecular biology techniques, proteomics or bioinformatics as well interests in molecular aspects of cancer research is essential.
We offer you:
- A varied and professionally demanding position in a state-of-the-art working environment
- Comprehensive on-the-job training provided by experienced and qualified colleagues
- The opportunity to take part in internal and external professional development courses
- An opportunity to work in the city centre of Munich with good access to public transport systems and benefits in the form of specially discounted public transport tickets
- Performance-related salary in accordance with the TV-L public-sector salary scale plus attractive benefits offered to public- sector employees
If the candidates’ suitability for the position in question is equal, severely disabled applicants shall be given preference. Interview-related costs can, unfortunately, not be reimbursed.
Please submit your complete application documents by e-mail to dieter.saur@tum.de quoting the position 1020:
Univ.-Prof. Dr. med Dieter Saur
Institut für Experimentelle Tumortherapie
Klinik und Poliklinik für Innere Medizin II
Klinikum rechts der Isar der Technischen Universität München
Ismaninger Straße 22
81675 München
E-Mail: dieter.saur@tum.de
The Department of Internal Medicine II, the Institute of Translational Cancer Research and Experimental Cancer Therapy at TUM and the German Cancer Research Center offer a PhD student (f/m/d) position in Computational Biology/Bioinformatics for translational cancer research with a focus on the analysis of single cell sequencing at the Center for Translational Cancer Research (TranslaTUM) in Munich.
We are deploying genetic models to study molecular, immunological and translational aspects of pancreatic cancer. We utilize these systems to uncover molecular mechanisms as well as inflammatory and immune pathways that are required for tumor initiation and -progression in vivo (e.g. Nature Reviews Cancer 2020, Oct;20(10):573-593, Nature 2018, 554:62-68; Nat. Commun. 2016, 7:10770; Nat Med. 2014, 20:1340-7; Cancer Cell. 2013,24:15-29, Cancer Cell. 2013,23:406-20, Nat Commun. 2013;4:1630; PNAS 2011, 108:9945-50). During the past decade, our lab has generated a comprehensive resource of pancreatic primary tumors and primary cell cultures. Multiple NGS methods have been performed to decipher the molecular makeup of these tumors. The advertised project focuses on unraveling tumor heterogeneity and its impact on treatment response and resistance using single cell sequencing techniques and will be performed in close collaboration with the Theis lab at the Helmoltz Center Munich.
The successful candidate will interact within a multidisciplinary environment of biologists, clinicians, computational scientists and mathematicians within the TranslaTUM. She/he will work closely with a diverse team to formulate hypotheses and validate predictions using genomic and transcriptomic assays. She/he will be exposed to cutting edge experimental methods to study translational aspects of cancer. She/he will be employed under the umbrella of the German Cancer Consortium (DKTK/DKFZ/TUM) as well as at the Institute for Experimental Cancer Therapy at Klinikum rechts der Isar university hospital of the Technical University of Munich (www.exp-cancertherapy.med.tum.de/en). The Institute is located at the newly built Center for Translational Cancer Research, TranslaTUM, in the heart of Munich.
Your responsibilities:
- Set up bioinformatics platforms and develop computational pipelines for the analysis of single cell RNA-sequencing and single cell DNA-sequencing datasets
- Integrate these datasets with molecular (WES, WGBS, lcWGS, ChIPseq, ATACseq), phenotypic (e.g. histology) and clinical information
- Apply bioinformatics techniques to published/unpublished data for the analysis and interpretation of omics datasets
- Aid researchers select and use computational and statistical tools relevant to their single cell sequencing projects
Your profile:
- Exceptional self-motivated computational scientist with a strong analytical background
- Previous exposure to and experience with bioinformatics as well interests in molecular aspects of cancer research are an asset, but not required
- Due to the interdisciplinary framework and close collaboration with wet-lab scientists, communicative skills are essential.
We offer you:
- A varied and professionally demanding position in a state-of-the-art working environment
- Comprehensive on-the-job training provided by experienced and qualified colleagues
- The opportunity to take part in internal and external professional development courses
- An opportunity to work in the city centre of Munich with good access to public transport systems and benefits in the form of specially discounted public transport tickets
- Performance-related salary in accordance with the TV-L public-sector salary scale plus attractive benefits offered to public- sector employees
If the candidates’ suitability for the position in question is equal, severely disabled applicants shall be given preference. Interview-related costs can, unfortunately, not be reimbursed.
Please submit your complete application documents by e-mail to dieter.saur@tum.de quoting the position 1021:
Univ.-Prof. Dr. med Dieter Saur
Institut für Experimentelle Tumortherapie
Klinik und Poliklinik für Innere Medizin II
Klinikum rechts der Isar der Technischen Universität München
Ismaninger Straße 22
81675 München
E-Mail: dieter.saur@tum.de